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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleProtective Effect Of Trifluoperazine On The Mitochondrial Damage Induced By Ca2+ Plus Prooxidants.pt_BR
dc.contributor.authorPereira, R Spt_BR
dc.contributor.authorBertocchi, A Ppt_BR
dc.contributor.authorVercesi, A Ept_BR
unicamp.authorR S Pereira, Departamento de Bioquimica, Universidade Estadual de Campinas, SP, Brazil.pt_BR
unicamp.author.externalA P Bertocchi,pt
unicamp.author.externalA E Vercesi,pt
dc.subjectAnimalspt_BR
dc.subjectCalciumpt_BR
dc.subjectCell Membrane Permeabilitypt_BR
dc.subjectIntracellular Membranespt_BR
dc.subjectKineticspt_BR
dc.subjectMembrane Potentialspt_BR
dc.subjectMembrane Proteinspt_BR
dc.subjectMitochondria, Liverpt_BR
dc.subjectMitochondrial Swellingpt_BR
dc.subjectOxidantspt_BR
dc.subjectOxygen Consumptionpt_BR
dc.subjectRatspt_BR
dc.subjectRats, Wistarpt_BR
dc.subjectSuccinatespt_BR
dc.subjectSulfhydryl Compoundspt_BR
dc.subjectTrifluoperazinept_BR
dc.description.abstractIsolated rat liver mitochondria undergo extensive swelling and disruption of membrane potential when they accumulate Ca2+ in the presence of a prooxidant such as diamide or t-butylhydroperoxide. The phenothiazinic drug trifluoperazine, at concentrations (15-35 microM) which do not inhibit respiration or the influx of Ca2+ into mitochondria, significantly protected mitochondria against the deleterious effects of Ca2+ plus a prooxidant. In contrast, at concentrations higher than 100 microM the drug potentiated these deleterious effects of Ca2+ and prooxidants and had a damaging effect per se on the inner mitochondrial membrane. It is proposed that the protection conferred by the drug is mediated by changes in membrane protein structure that decrease the production of protein thiol cross-linkings which occur when mitochondria accumulate calcium under oxidant stress conditions.en
dc.relation.ispartofBiochemical Pharmacologypt_BR
dc.relation.ispartofabbreviationBiochem. Pharmacol.pt_BR
dc.date.issued1992-Novpt_BR
dc.identifier.citationBiochemical Pharmacology. v. 44, n. 9, p. 1795-801, 1992-Nov.pt_BR
dc.language.isoengpt_BR
dc.description.volume44pt_BR
dc.description.firstpage1795-801pt_BR
dc.rightsfechadopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn0006-2952pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/1449534pt_BR
dc.date.available2015-11-27T12:18:12Z-
dc.date.accessioned2015-11-27T12:18:12Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T12:18:12Z (GMT). No. of bitstreams: 1 pmed_1449534.pdf: 921876 bytes, checksum: a64b82cd376cc42c441d11ed812b3209 (MD5) Previous issue date: 1992en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/193654-
dc.identifier.idPubmed1449534pt_BR
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