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Type: Artigo de periódico
Title: Protective Effect Of Trifluoperazine On The Mitochondrial Damage Induced By Ca2+ Plus Prooxidants.
Author: Pereira, R S
Bertocchi, A P
Vercesi, A E
Abstract: Isolated rat liver mitochondria undergo extensive swelling and disruption of membrane potential when they accumulate Ca2+ in the presence of a prooxidant such as diamide or t-butylhydroperoxide. The phenothiazinic drug trifluoperazine, at concentrations (15-35 microM) which do not inhibit respiration or the influx of Ca2+ into mitochondria, significantly protected mitochondria against the deleterious effects of Ca2+ plus a prooxidant. In contrast, at concentrations higher than 100 microM the drug potentiated these deleterious effects of Ca2+ and prooxidants and had a damaging effect per se on the inner mitochondrial membrane. It is proposed that the protection conferred by the drug is mediated by changes in membrane protein structure that decrease the production of protein thiol cross-linkings which occur when mitochondria accumulate calcium under oxidant stress conditions.
Subject: Animals
Cell Membrane Permeability
Intracellular Membranes
Membrane Potentials
Membrane Proteins
Mitochondria, Liver
Mitochondrial Swelling
Oxygen Consumption
Rats, Wistar
Sulfhydryl Compounds
Citation: Biochemical Pharmacology. v. 44, n. 9, p. 1795-801, 1992-Nov.
Rights: fechado
Date Issue: 1992
Appears in Collections:Unicamp - Artigos e Outros Documentos

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