Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/193599
Type: Artigo de periódico
Title: Supersensitivity To Isoprenaline And Epinephrine In Right Atria Isolated From Rats Submitted To A Single Swimming Session.
Author: Spadari, R C
Bassani, R A
De Moraes, S
Abstract: 1. The effects of swim-induced stress on rat atrial norepinephrine content, plasma corticosterone level and pacemaker sensitivity to catecholamines were studied. 2. Swimming for 50 min reduced the atrial norepinephrine content and induced a long-lasting increase in the plasma corticosterone level. 3. Pacemakers isolated from swim stressed rats showed supersensitivity to the chronotropic effect of isoprenaline. Sensitivity to norepinephrine was not significantly altered. Bilateral adrenalectomy or metyrapone pretreatment prevented the development of swimming-induced supersensitivity to isoprenaline. After in vitro denervation and addition of cocaine supersensitivity to epinephrine was demonstrated. 4. It is concluded that corticosterone, at least partially, mediates the supersensitivity to isoprenaline and epinephrine in pacemaker isolated from acutely swim stressed rats.
Subject: Adrenalectomy
Animals
Corticosterone
Epinephrine
Heart
Isoproterenol
Male
Metyrapone
Myocardium
Norepinephrine
Physical Exertion
Rats
Rats, Inbred Strains
Stress, Physiological
Swimming
Citation: General Pharmacology. v. 19, n. 1, p. 129-35, 1988.
Rights: fechado
Address: http://www.ncbi.nlm.nih.gov/pubmed/3345899
Date Issue: 1988
Appears in Collections:Unicamp - Artigos e Outros Documentos

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