Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/193587
Type: Artigo de periódico
Title: Repeated Swimming Stress And Responsiveness Of The Isolated Rat Pacemaker To The Chronotropic Effect Of Noradrenaline And Isoprenaline: Role Of Adrenal Corticosteroids.
Author: Spadari, R C
De Moraes, S
Abstract: 1. Repeated swimming stress (three daily sessions) resulted in an increased plasma corticosterone level and subsensitivity of the isolated rat pacemaker to noradrenaline and isoprenaline. 2. Repeated swimming stress was found to decrease the affinity of beta 1-adrenoreceptors for metoprolol. 3. Bilateral adrenalectomy performed 2 days before repeated swimming stress abolished the development of pacemaker subsensitivity to noradrenaline and isoprenaline and the decrease in beta 1-adrenoreceptors affinity for metoprolol. 4. It is concluded that adrenal corticosteroids, at least partially, mediate the swimming stress-induced subsensitivity of the isolated rat pacemaker to noradrenaline and isoprenaline.
Subject: Adrenalectomy
Animals
Corticosterone
Heart Conduction System
Heart Rate
Isoproterenol
Male
Metoprolol
Norepinephrine
Rats
Rats, Inbred Strains
Receptors, Adrenergic, Beta
Stress, Physiological
Swimming
Citation: General Pharmacology. v. 19, n. 4, p. 553-7, 1988.
Rights: fechado
Address: http://www.ncbi.nlm.nih.gov/pubmed/2842218
Date Issue: 1988
Appears in Collections:Unicamp - Artigos e Outros Documentos

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