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Type: Artigo de periódico
Title: A Strong Protective Action of Guttiferone-A, a Naturally Occurring Prenylated Benzophenone, Against Iron-Induced Neuronal Cell Damage
Author: FIGUEREDO, Yanier Nunez
RUBIO, Osmany Cuesta
HERNANDEZ, Rene Delgado
NAAL, Zeki
CURTI, Carlos
ANDREU, Gilberto L. Pardo
Abstract: Guttiferone-A (GA) is a natural occurring polyisoprenylated benzophenone with several reported pharmacological actions. We have assessed the protective action of GA on iron-induced neuronal cell damage by employing the PC12 cell line and primary culture of rat cortical neurons (PCRCN). A strong protection by GA, assessed by the 2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carbox-anilide (XTT) assay, was revealed, with IC(50) values <1 mu M. GA also inhibited Fe(3+)-ascorbate reduction, iron-induced oxidative degradation of 2-deoxiribose, and iron-induced lipid peroxidation in rat brain homogenate, as well as stimulated oxygen consumption by Fe(2+) autoxidation. Absorption spectra and cyclic voltammograms of GA Fe(2+)/Fe(3+) complexes suggest the formation of a transient charge transfer complex between Fe(2+) and GA, accelerating Fe(2+) oxidation. The more stable Fe(3+) complex with GA would be unable to participate in Fenton-Haber Weiss-type reactions and the propagation phase of lipid peroxidation. The results show a potential of GA against neuronal diseases associated with iron-induced oxidative stress.
Subject: guttiferone-A
iron chelation
Country: Japão
Citation: JOURNAL OF PHARMACOLOGICAL SCIENCES, v.116, n.1, p.36-46, 2011
Rights: fechado
Identifier DOI: 10.1254/jphs.10273FP
Date Issue: 2011
Appears in Collections:IQ - Artigos e Outros Documentos

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