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Type: Artigo de periódico
Title: Marine Fungi Aspergillus sydowii and Trichoderma sp Catalyze the Hydrolysis of Benzyl Glycidyl Ether
Author: MARTINS, Mariana Provedel
MOUAD, Ana Maria
SELEGHIM, Mirna Helena Regali
SETTE, Lara Duraes
PORTO, Andre Luiz Meleiro
Abstract: Whole cells of the marine fungi Aspergillus sydowii Gc12, Penicillium raistrickii Ce16, P. miczynskii Gc5, and Trichoderma sp. Gc1, isolated from marine sponges of the South Atlantic Ocean (Brazil), have been screened for the enzymatic resolution of (+/-)-2-(benzyloxymethyl)oxirane (benzyl glycidyl ether; 1). Whole cells of A. sydowii Gc12 catalyzed the enzymatic hydrolysis of (R,S)-1 to yield (R)-1 with an enantiomeric excess (ee) of 24-46% and 3-(benzyloxy)propane-1,2-diol (2) with ee values < 10%. In contrast, whole cells of Trichoderma sp. Gc1 afforded (S)-1 with ee values up to 60% and yields up to 39%, together with (R)-2 in 25% yield and an ee of 32%. This is the first published example of the hydrolysis of 1 by whole cells of marine fungi isolated from the South Atlantic Ocean. The hydrolases from the two studied fungi exhibited complementary regioselectivity in opening the epoxide ring of racemic 1, with those of A. sydowii Gc12 showing an (S) preference and those of Trichoderma sp. Gc1 presenting an (R) preference for the substrate.
Subject: Marine fungi
Aspergillus sydowii
Trichoderma sp.
Country: Estados Unidos
Citation: MARINE BIOTECHNOLOGY, v.13, n.2, p.314-320, 2011
Rights: fechado
Identifier DOI: 10.1007/s10126-010-9302-2
Date Issue: 2011
Appears in Collections:CPQBA - Artigos e Outros Documentos

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