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|Type:||Artigo de periódico|
|Title:||Bioreduction of alpha-chloroacetophenone by whole cells of marine fungi|
|Author:||ROCHA, Lenilson C.|
FERREIRA, Hercules V.
PIMENTA, Eli F.
BERLINCK, Roberto G. S.
SELEGHIM, Mirna H. R.
JAVAROTI, Darci C. D.
SETTE, Lara D.
BONUGLI, Rafaella C.
PORTO, Andre L. M.
|Abstract:||The asymmetric reduction of 2-chloro-1-phenylethanone (1) by seven strains of marine fungi was evaluated and afforded (S)-(-)-2-chloro-1-phenylethanol with, in the best case, an enantiomeric excess of 50% and an isolated yield of 60%. The ability of marine fungi to catalyse the reduction was directly dependent on growth in artificial sea water-based medium containing a high concentration of Cl(-) (1.2 M). When fungi were grown in the absence of artificial sea water, no reduction of 1 by whole cells was observed. The biocatalytic reduction of 1 was more efficient at neutral rather than acidic pH values and in the absence of glucose as co-substrate.|
|Citation:||BIOTECHNOLOGY LETTERS, v.31, n.10, p.1559-1563, 2009|
|Appears in Collections:||CPQBA - Artigos e Outros Documentos|
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