Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/1160
Type: Artigo de periódico
Title: Bioreduction of alpha-chloroacetophenone by whole cells of marine fungi
Author: ROCHA, Lenilson C.
FERREIRA, Hercules V.
PIMENTA, Eli F.
BERLINCK, Roberto G. S.
SELEGHIM, Mirna H. R.
JAVAROTI, Darci C. D.
SETTE, Lara D.
BONUGLI, Rafaella C.
PORTO, Andre L. M.
Abstract: The asymmetric reduction of 2-chloro-1-phenylethanone (1) by seven strains of marine fungi was evaluated and afforded (S)-(-)-2-chloro-1-phenylethanol with, in the best case, an enantiomeric excess of 50% and an isolated yield of 60%. The ability of marine fungi to catalyse the reduction was directly dependent on growth in artificial sea water-based medium containing a high concentration of Cl(-) (1.2 M). When fungi were grown in the absence of artificial sea water, no reduction of 1 by whole cells was observed. The biocatalytic reduction of 1 was more efficient at neutral rather than acidic pH values and in the absence of glucose as co-substrate.
Subject: Biocatalysis
Bioreduction
Chlorohydrin
Marine fungi
Country: Holanda
Editor: SPRINGER
Citation: BIOTECHNOLOGY LETTERS, v.31, n.10, p.1559-1563, 2009
Rights: fechado
Identifier DOI: 10.1007/s10529-009-0037-y
Address: http://dx.doi.org/10.1007/s10529-009-0037-y
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Date Issue: 2009
Appears in Collections:CPQBA - Artigos e Outros Documentos

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