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Type: Artigo de periódico
Title: Biotransformation of alpha-Bromoacetophenones by the Marine Fungus Aspergillus sydowii
Author: ROCHA, Lenilson Coutinho
FERREIRA, Hercules Vicente
PIMENTA, Eli Fernando
BERLINCK, Roberto Gomes Souza
REZENDE, Maria Olimpia Oliveira
LANDGRAF, Maria Diva
SELEGHIM, Mirna Helena Regali
SETTE, Lara Duraes
PORTO, Andre Luiz Meleiro
Abstract: The biotransformation reactions of alpha-bromoacetophenone (1), p-bromo-alpha-bromoacetophenone (2), and p-nitro-alpha-bromoacetophenone (3) by whole cells of the marine fungus Aspergillus sydowii Ce19 have been investigated. Fungal cells that had been grown in artificial sea water medium containing a high concentration of chloride ions (1.20 M) catalysed the biotransformation of 1 to 2-bromo-1-phenylethanol 4 (56%), together with the alpha-chlorohydrin 7 (9%), 1-phenylethan-1,2-diol 9 (26%), acetophenone 10 (4%) and phenylethanol 11 (5%) identified by GC-MS analysis. In addition, it was observed that the enzymatic reaction was accompanied by the spontaneous debromination of 1 to yield alpha-chloroacetophenone 5 (9%) and alpha-hydroxyacetophenone 6 (18%) identified by GC-FID analysis. When 2 and 3 were employed as substrates, various biotransformation products were detected but the formation of halohydrins was not observed. It is concluded that marine fungus A. sydowii Ce19 presents potential for the biotransformations of bromoacetophenone derivatives.
Subject: Marine fungus
Aspergillus sydowii
Country: Estados Unidos
Citation: MARINE BIOTECHNOLOGY, v.12, n.5, p.552-557, 2010
Rights: fechado
Identifier DOI: 10.1007/s10126-009-9241-y
Date Issue: 2010
Appears in Collections:CPQBA - Artigos e Outros Documentos

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