Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/1120
Type: Artigo de periódico
Title: Synthesis Optimization of Hydroxymethylnitrofurazone, an Antichagasic Candidate, Using 3(2) Factorial Design
Author: TROSSINI, Gustavo H. G.
GIAROLLA, Jeanine
REZENDE, Leandro de
AMARAL, Antonia T. do
ZAIM, Marcio H.
BRUNS, Roy E.
FERREIRA, Elizabeth I.
Abstract: Hydroxymethylnitrofurazone presents in vitro activity against Trypanosoma cruzi. The optimization of the synthesis of this compound was performed through a 3(2) factorial statistical design. Quadratic model produced the best response surface predicting a maximum yield (82%) close to the center design point with a seven hours reaction and a 1:1.5 (NF:K(2)CO(3)) ratio.
Subject: Factorial design
synthesis optimization
hydroxymethylnitrofurazone (NFOH)
antichagasic candidate
response surface methodology
Country: Emirados Árabes Unidos
Editor: BENTHAM SCIENCE PUBL LTD
Citation: LETTERS IN ORGANIC CHEMISTRY, v.7, n.3, p.191-195, 2010
Rights: fechado
Address: http://apps.isiknowledge.com/InboundService.do?Func=Frame&product=WOS&action=retrieve&SrcApp=EndNote&UT=000277156400002&Init=Yes&SrcAuth=ResearchSoft&mode=FullRecord
http://apps.isiknowledge.com/InboundService.do?Func=Frame&product=WOS&action=retrieve&SrcApp=EndNote&UT=000277156400002&Init=Yes&SrcAuth=ResearchSoft&mode=FullRecord
Date Issue: 2010
Appears in Collections:IQ - Artigos e Outros Documentos

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