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Type: Artigo de periódico
Title: Quality Of Life And Adverse Events After Radiotherapy In Gynecologic Cancer Survivors: A Cohort Study
Author: Vaz A.F.
Conde D.M.
Costa-Paiva L.
Morais S.S.
Esteves S.B.
Pinto-Neto A.M.
Abstract: Purpose: To evaluate quality of life (QOL) in gynecologic cancer survivors after radiotherapy (RT), investigate the frequency of adverse events and demonstrate an association between these symptoms and QOL. Methods: A prospective cohort study of 95 women aged 21-75 years undergoing RT for gynecologic cancer was carried out. QOL was assessed by the WHOQOL-BREF before, at 4 months, 1 year and 3 years after RT and adverse events were evaluated following RT by the (CTCAE) v 3.0 scale. QOL scores were assessed by the Wilcoxon signed rank test over time. Multiple linear regression analysis was used to identify predictors of QOL. Results: The most frequent adverse events were pain (64.2%) and dyspareunia (45.9%). A significant increase in QOL scores was observed in the psychological domain, general health and overall QOL. Pain was negatively associated with the physical, psychological and social relationship domains (p < 0.01); dyspareunia with the physical and social relationship (p < 0.01); decreased sexual interest with the psychological (p < 0.01). Higher family income was positively associated with the psychological domain and general health (p < 0.01). Conclusions: Results suggested that QOL improved after RT in women with gynecologic cancer. Adverse events, such as pain, dyspareunia and decreased sexual interest had a negative impact on QOL. © Springer-Verlag 2011.
Citation: Archives Of Gynecology And Obstetrics. , v. 284, n. 6, p. 1523 - 1531, 2011.
Rights: fechado
Identifier DOI: 10.1007/s00404-011-1886-x
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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