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Type: Artigo de periódico
Title: A Reliable Ex Vivo Invasion Assay Of Human Reticulocytes By Plasmodium Vivax
Author: Russell B.
Suwanarusk R.
Borlon C.
Costa F.T.M.
Chu C.S.
Rijken M.J.
Sriprawat K.
Warter L.
Koh E.G.L.
Malleret B.
Colin Y.
Bertrand O.
Adams J.H.
D'Alessandro U.
Snounou G.
Nosten F.
Renia L.
Abstract: Currently, there are no reliable RBC invasion assays to guide the discovery of vaccines against Plasmodium vivax, the most prevalent malaria parasite in Asia and South America. Here we describe a protocol for an ex vivo P vivax invasion assay that can be easily deployed in laboratories located in endemic countries. The assay is based on mixing enriched cord blood reticulocytes with matured, trypsin-treated P vivax schizonts concentrated from clinical isolates. The reliability of this assay was demonstrated using a large panel of P vivax isolates freshly collected from patients in Thailand. © 2011 by The American Society of Hematology.
Citation: Blood. , v. 118, n. 13, p. e74 - e81, 2011.
Rights: fechado
Identifier DOI: 10.1182/blood-2011-04-348748
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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