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Type: Artigo de periódico
Title: An Efficient Procedure For The Synthesis Of 2-n-boc-amino-3,5-diols
Author: Dias L.C.
Fattori J.
Perez C.C.
de Oliveira V.M.
Aguilar A.M.
Abstract: We wish to describe here the diastereoselective reaction between chiral N-Boc-α-amino aldehydes with both achiral allyltrichlorostannanes leading to 1,2-syn-N-Boc-α-amino alcohols, which are easily converted to the corresponding 4-N-Boc-amino-3-hydroxy ketones after treatment with catalytic amounts of OsO4 in the presence of NaIO4. After reduction of the carbonyl function, these 4-N-Boc-amino-3-hydroxy ketones were converted to 1-deoxy-5-hydroxy sphingosine analogues. © 2008 Elsevier Ltd. All rights reserved.
Citation: Tetrahedron. , v. 64, n. 25, p. 5891 - 5903, 2008.
Rights: fechado
Identifier DOI: 10.1016/j.tet.2008.04.049
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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