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Type: Artigo de periódico
Title: Multicenter Evaluation Of Efficacy And Toleration Of Aceclofenac In Knee Osteoarthritis: Study Of 97 Patients [avaliacao Multicentrica Da Eficacia E Tolerabilidade Do Aceclofenaco Em Osteoartrite Do Joelho: Estudo De 97 Pacientes]
Author: Neto J.F.M.
Donadio P.R.
Loures M.A.A.D.R.
Issa M.M.M.
Ribeiro A.C.M.
Carvalho M.A.P.
Baaklini C.E.
Schincariol N.B.
Abstract: Treatment of osteoarthritis is usually symptomatic; however growing interest is being raised on NSAIDs action over articular cartilage. Aceclofenac has been shown in vitro to play a favorable role over articular cartilage, increasing GAG synthesis. Preclinical and clinical studies have shown aceclofenac to be better tolerated than others in the same therapeutic class. Considering this, it was decided to conduct a multicenter study of aceclofenac in management of knee osteoarthritis. Five centers participated evaluating a total of 97 patients. Most of the patients showed clear clinical improvement, demonstrating a good potency profile. The results allow us to say that in this clinical study aceclofenac was shown to be safe and well tolerated.
Citation: Revista Brasileira De Medicina. , v. 54, n. 3, p. 150 - 157, 1997.
Rights: fechado
Date Issue: 1997
Appears in Collections:Unicamp - Artigos e Outros Documentos

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